It’s those moments of unexpected magic that have helped fuel my entire year. We played on a couple of each other’s tunes, and she let me write a verse for one of hers. Another really special experience was when Ellie Jackson and I played a show at Circle-A to a packed room with a really engaged crowd. I played Cactus Club for the first time with Honey Creek and The Sinner And The Saint, and the response totally blew me away. Nathan Honoré: Most of the highlights stem from playing live, meeting new artists, and collaborating. What are some of the highlights or standout experiences for the project from the past 12 months? Milwaukee Record: It’s been almost exactly a year since you released your debut full-length. Prior to today’s release of Nowhere To Run and before Next Paperback Hero’s release show at Linneman’s on October 1, Honoré told Milwaukee Record about artistic highlights from the last 12 months, his decision to involve others in his solo venture, what it’s like to hear his songs on the radio, and goals he’s set for the near future. In doing so, the once-solitary creator has opened himself up to collaborating with others in ways he wouldn’t have before. That EP, Nowhere To Run, is a three-song follow-up that finds Honoré taking his project to exciting new territory. Today, almost exactly one year removed from putting out that album, Honoré released a new Next Paperback Hero EP into the world. That album, the self-recorded Morning Skies & Heavy Eyes, found the multi-instrumentalist doing pretty much everything on a 35-minute release spanning nine meticulously crafted songs. Relive the epic (if ultimately tragic) story of Victoria and Ashland in the gallery below.Last September, Nathan Honoré-a Milwaukee singer-songwriter who performs under the Next Paperback Hero namesake-released his debut full-length. And that was his driving force from Day 1.” He didn’t plan it that way, he didn’t start it that way, but he genuinely fell in love with her and cares about her and wants to be with her. Is this still part of the con? ‘Is there any part of him that’s still sort of playing the game with her?’ And he was like, ‘Nope, everything with her is real. Newman says he pushed hard on that last question. And then the other thing that was really important was that his love for Victoria was real.” The interview - which can be viewed in its entirety below - goes on to hit upon numerous topics, including one that has been hotly debated among fans: Did Ashland ever truly love Victoria? “The two things that gave me were that he was completely blindsided by the revelation about his son not being his biological son, and that changed the way he looks at the world. More: We recap Fox’s sexy new country music soap ” It didn’t help that he was away from family and living in Los Angeles, a place he “had no interest” in living. “I definitely made the right decision by keeping it. “About halfway through my run with Young & Restless, let’s just put it this way: I was glad that I didn’t signed on for a longer period of time,” he reflects. “And actually, Britt said to me, ‘You know honey, I kinda feel like you put so many years of your life into the show, I think you should be on the last episode of Guiding Light.”Īs fans know, he ultimately decided to stay and, in fact, was featured in the final scene as Josh and Reva (Kim Zimmer) were seen driving away from Springfield and the town’s iconic lighthouse as the words “The End” appeared on screen. ![]() ![]() “I was deciding whether or not to resign or to just let it all go, because I had a pretty good idea the show was going to go off the air,” he reflected. More: The passion twist that’ll rock Genoa Cityīack then, it was wife Britt Helfer who convinced him to stick it out. “I started getting that sense of, ‘Oh yeah, I’ve done this. About halfway through his relatively short stint in Genoa City, Newman says he got a very familiar feeling. Having stepped in as a recast when Richard Burgi wound up having to exit, Newman wasn’t looking for another decades-long run like the one he’d had as Guiding Light leading man Josh Lewis.ĭuring a revealing chat with The Locher Room host Alan Locher, the actor opened up about a wide variety of topics, speaking honestly about his time on both shows… even admitting that he’d considered exiting Guiding Light before that iconic show’s final episode. Ashland’s death may have come as a shock to many Young & Restless viewers, but the same can’t be said for portrayer Robert Newman.
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![]() (A) Timeline of ancient Southwest Asian individuals used in the analyses. Spatio-temporal distribution of the samples and the population structure of Neolithic Southwest Asia. With the exception of a single ancient DNA study reporting 15 mitochondrial DNA sequences from the Upper Euphrates ( 14), Upper Mesopotamia has remained genomically unexplored, mostly owing to low DNA preservation in the region.įig. Meanwhile, key questions about the possible roles of Upper Mesopotamia in interregional demographic and cultural change, e.g., whether Upper Mesopotamia influenced Late Neolithic Central Anatolia and whether it was the source of the post-Neolithic gene flow into Anatolia ( 6, 13), have remained open. This body of work has together revealed (a) genetically distinct populations in all three regions, (b) a dominant trend of population continuity between pre-Neolithic, Pre-Pottery Neolithic (PPN) and Pottery Neolithic (PN) communities, (c) an overlay of interregional gene flow through time, such as inferred “southern” and “eastern” gene flow events into Central Anatolia between the Early and Late Neolithic. This stands in contrast with a significant number of recent archaeogenomic studies that focused on the three most distant corners of Neolithic Southwest Asia, namely South Levant, Central Zagros, and Central Anatolia ( Fig. 9800-6500 BC) is well documented in the archaeological record, but their demographic history and social structures has remained unknown owing to the lack of genomes from North Mesopotamia. The innovative spirit and cultural dynamism of these societies during the Neolithic Transition in Southwest Asia (c. Located between the Euphrates and Tigris rivers, the hilly flanks of Upper Mesopotamia were home to the earliest sedentary hunter-gatherers who built the first monumental structures at Göbekli Tepe ( 1) and domesticated numerous local plant and animal species, including einkorn, emmer, sheep, goat, pig, and cattle ( 2– 5). We hypothesise that Upper Mesopotamia’s cultural dynamism during the Neolithic Transition was the product not only of its fertile lands but also of its interregional demographic connections. Finally, we identify Upper Mesopotamia as the likely source of eastern gene flow into Neolithic Anatolia, in line with material culture evidence. We document bodily interventions such as head-shaping and cauterization among the individuals examined, reflecting Çayönü’s cultural ingenuity. Our results further suggest that the community was organised along biological family lines. Our findings reveal that Çayönü was a genetically diverse population, carrying a mixed ancestry from western and eastern Fertile Crescent, and that the community received immigrants. We present thirteen ancient genomes (c.8500-7500 calBCE) from Pre-Pottery Neolithic Çayönü in the Tigris basin together with bioarchaeological and material culture data. Upper Mesopotamia played a key role in the Neolithic Transition in Southwest Asia through marked innovations in symbolism, technology, and foodways. Topaz DeJPEG – Ever taken a photo with your cell phone or a point & shoot and you could just *tell* how low-quality it was? It looks all pixely? DeJPEG will fix that up in a second!Ĭlick the links above to see the incredible before and afters you can do with each plugin.Īnd the best part is that Topaz is compatible with a number of platforms and programs. Topaz Clean – create some seriously fun photos with textures and detail manipulation! Topaz ReMask – Okay, so cool! Have you ever taken a picture, but the background was so-so? Use ReMask to easily crop out your subject and paste it on a different background! :) How fun! I know any noise/grain will be taken care of by DeNoise! I never have to worry about shooting with a high ISO. Topaz DeNoise – instantly remove noise and preserve details. Topaz Detail – enhance details, add depth, and achieve unbelievable crispness in your photos. Topaz Simplify – add creative simplification, art effects, and line accentuation to your photos for easy one-of-a-kind art. Topaz Adjust – optimize image exposure, color, and detail for stunning image results! Just see above! :) And today, the seriously fun & talented folks at Topaz would like to offer one Kevin & Amanda reader their entire plugin bundle suite!! ($179.99 value) There’s so much you can do with all the Topaz plugins. If you like what you see, click OK…Īnd just like that, I had this! I am so in love with these vibrant colors!! And it was seriously that simple! :) ![]() There are so many fun options to chose from! :) For this pic, I clicked Exposure Color Stretch. To use Topaz in Photoshop, just click on Filter from the menu bar, and you’ll see all the Topaz plugins you can choose from. ![]() Here’s the original, SOOC (straight out of camera) photo. Just look what I did with one of my recent Chicago photos… I use it often in my day-to-day photo editing to add some serious WOW factor to my photos! :) Hey guys! I am beyond excited to share this giveaway with you today! The Topaz Labs Plugin Bundle is one of my favorite photo editing tools. ![]() Did you know you can download the Topaz plugins for a free trial to try out and make sure you are 100% happy with it before you buy? :) Go ahead. Guess what! Topaz has offered Kevin & Amanda readers a special discount! Use the coupon code kevinandamanda to get 15% off all Topaz products. Time’s up! The winner of the Topaz Plugin Bundle is entry #848, Maureen Henry! 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![]() ![]() Many computer problems are caused by missing or outdated device drivers, especially in Windows 11. ![]() Next, update individual drivers or all of the necessary drivers with one click. When the scan is complete, the driver update utility will display a results page showing which drivers are missing or out-of-date: Once you download and run the utility, it will scan for out-of-date or missing drivers: It will Update all of your drivers in just a few clicks, and even backup your drivers before making any changes. The Driver Update Utility automatically finds, downloads and installs the right driver for your hardware and operating system. Automatic updates could save you hours of time. If you are having trouble finding the right driver, stop searching and fix driver problems faster with the Automatic Driver Update Utility. Many device drivers are not updated through the Microsoft Windows Update service. Visit our Driver Support Page for helpful step-by-step videos Install Drivers Automatically In most cases, you will need to reboot your computer in order for the driver update to take effect. Locate the device and model that is having the issue and double-click on it to open the Properties dialog box.Ĭlick the Update Driver button and follow the instructions. In Windows XP, click Start -> Control Panel -> Performance and Maintenance -> System -> Hardware tab -> Device Manager button In Windows Vista, click Start -> Control Panel -> System and Maintenance -> Device Manager In Windows 7, click Start -> Control Panel -> Hardware and Sound -> Device Manager In Windows 8, swipe up from the bottom, or right-click anywhere on the desktop and choose "All Apps" -> swipe or scroll right and choose "Control Panel" (under Windows System section) -> Hardware and Sound -> Device Manager In Windows 11, Windows 10 & Windows 8.1, right-click the Start menu and select Device Manager It allows you to see all of the devices recognized by your system, and the drivers associated with them. To install a driver in Windows, you will need to use a built-in utility called Device Manager. Once you download your new driver, then you need to install it. ![]() ![]() However, the El Camino has not officially returned to the market in any other territory. This is largely due to the vehicle's popularity laying in its simplicity and lack of unnecessary extras The Future of the El CaminoĬhevrolet have, for many years, toyed with the idea of a new and improved El Camino in Australia, a loose variant (the Holden) is already available. Later, in 1996, an attempt was made to fuse the Chevrolet El Camino with an Impala after test runs, this was also not put ahead for mass production.įor such a large scale model of vehicle, there are surprisingly few editions outside of the stock variant available 'out of the showroom'. In 1992, a Lumina influenced edition was released, but with a front wheel drive system it received overwhelmingly negative reviews. Chevrolet El Camino Results (0) No auctions match. ![]() Thus, by 1987, the body of the Chevrolet El Camino was lighter, slimmer and less bulky.Ĭoncept editions of the Chevrolet El Camino were tested and released over the years. Chevrolet El Camino Auctions (0) No live auctions save this search to get notified when a new listing goes live. Mileage Unavailable Classic Rides & Rods Annandale, MN Get a Free Vehicle History Report 1968 Chevrolet El Camino 24,900 432 /mo 21,750 miles Days Listed 17 Price 16,883 below avg. Whilst the body remained largely the same, Oldsmobile offered diesel engines as an optional extra, and the size of the body gradually trimmed over the second generation's years of production in line with rising fuel costs. 1986 Chevrolet El Camino 18,500 321 /mo Email for Mileage Drivetrain: RWD Days Listed 37 Price 1,670 below avg. The Chevrolet El Camino bore several editions and variants. Production was shifted to Mexico in 1986 before ceasing altogether on a low key shutdown in 1987. In 1984, a smaller version of the car was reintroduced into the market, with the new Chevrolet El Camino based on several other smaller Chevrolet models. However, by 1960, production had plummeted and the model was discontinued shortly after. Initially, production was successful, with thousands of customers worldwide rushing to pick up the Chevrolet El Camino. The El Camino was born from several brands racing to create a car that was equally popular with farmers as it would be with young, sporty Americans who wanted an ell encompassing vehicle. Built initially between 19, the El Camino picked up for a longer run between 19 when production finally ceased due to lower demand, changing customer habits and production costs. The Chevrolet El Camino is possibly one of the most recognised sport and pickup vehicle crossovers in American history. ![]() Also NLR and PLR may be related to chemosensitivity. Many studies have shown that elevated inflammatory markers, such as neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR), are associated with poor prognosis in patients with different solid malignancies. It is well recognized that systemic inflammation plays an important role in promoting tumor progression. Among them, while luminal A tumors have been reported to be the least likely to achieve pCR after neoadjuvant therapy, followed by luminal B tumors–which show a moderate response-, Her2-enriched and TN tumors exhibit the highest pCR rates. However, achieving a pCR after neoadjuvant therapy is associated with several pathologic and biologic factors such as histologic grade, hormone receptor status, and expression of Her2 and Ki67, among others. In the United States, the Food and Drug Administration (FDA) has recommended inclusion of pathologic complete response (pCR) as a main requirement for the accelerated approval of drugs used for neoadjuvant therapy in early-stage, high-risk breast cancer. Pathological complete response (pCR) to neoadjuvant chemotherapy in breast cancer patients is of prognostic value in determining short-, and mid-term outcomes, and is one of the main objectives in current ongoing studies assessing the potential benefit of neoadjuvant chemotherapy. Our results suggest that breast cancer patients with low platelet-to-lymphocyte ratio (PLR <150), treated with neoadjuvant chemotherapy achieve higher complete pathological response, independently of primary tumor molecular subtype. In addition, Her2-enriched tumors achieved the highest pCR rates (65%), followed by TN (34%) tumors. PLR was not associated with age, menopausal status, baseline tumor size, histologic grade, axillary lymph node involvement, disease stage, estrogen receptor status, or Ki67 however, complete pathological response was significantly higher in the low PLR group (PLR<150) compared with the high PLR group (35.1% Vs. In our cohort, the most frequent tumor molecular subtype was luminal B/Her2- (27.8%) followed by triple negative (21.5%), luminal B/Her2+ (19.8%), Her2-enriched (16%) and luminal A (13.5%). Disease was locally advanced in 83% of the participants, and 77.7% had compromised lymph nodes. A total of 288 patients were included in the study, with a median age of 51 years old. Therefore, in this study we performed a cross-sectional study and analyzed the association between inflammatory biomarkers and pCR (pathological complete response) in patients diagnosed with breast cancer–of different molecular subtypes- and treated with neoadjuvant chemotherapy. Currently, there are no studies in Colombian patients reporting the role of inflammatory biomarkers as response predictors in patients receiving neoadjuvant chemotherapy. Inflammatory biomarkers, such as platelet-to-lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR), have been proposed as predictive factors of response to neoadjuvant chemotherapy. Response to neoadjuvant chemotherapy in breast cancer patients is of prognostic value in determining short- and mid-term outcomes. ![]() So far people are saying, that is not that great. ![]() The controller cradles your smartphone which becomes the screen, pretty much like the Nintendo Switch. Next you have to select what type of smartphone to use it with Android or iOS. both theses designs have the buttons matching. There are 4 varieties of the controller, the Xbox black version or the PlayStation 5 DualSense white version. That’s bound to be a huge boost for Backbone as a young gaming startup.Have you ever wished you could only use a single controller for all you gaming needs? Well that wish almost got granted, but do not despair, Backbone is pretty close with the Backbone One mobile controller. The Microsoft tie up means that someone who purchases the Backbone for $99 from its website or at Microsoft Stores today gets 3 months of Game Pass Ultimate, making this the absolute best deal for new customers considering GPU is $45 alone. It would be a killer acquisition onramp for new players. It’s also making me yearn for a time when discovering games goes beyond ‘downloading’ them and into a world where I can see a clip shared by a friend, tap on it and be playing a single level or match that gets me hooked before having to go buy the game. This is how internet native players want to find and play new games - a continuously hyperlinked world of games and streams that makes it possible to see, follow and play without having to stop to manually search for anything. They’ve also got a really slick linking mechanism that allows you to download apps right from the App Store if you see a clip of them being shared on your feed. The experience of discovering, downloading and playing a game is better with a Backbone installed than even Apple Arcade now that the team is getting more into curation. I’ve personally played a lot of Destiny 2 over Stadia on Backbone and it feels fantastic, I can’t wait for it to be more directly integrated into the dash with clipping and social like the Xbox cloud titles are today. The way that Backbone unifies gaming experiences across AAA iOS ports like Warzone or Minecraft, Xbox and Playstation Remote Play and now native xCloud games feels like the way of the future for mobile gaming in a way that none of the individual players, including Apple, has managed to get right.Įven though xCloud games are web based they are treated and presented as native apps inside Backbone’s really well done dashboard. ![]() ![]() The game controller pedigree of the team shows (some original Xbox 360 controller team members worked on Backbone) but the software aspects are the most impressive. The Backbone team continues to impress with its slick and clever integrations and solid instincts. The package even makes use of an AppClip to display an AR version of Backbone running xCloud for people happening on the retail packaging at a store. There’s also a big callout for Xbox Remote Play, a feature that’s still super under-utilized and actually quite good on current-gen consoles. There’s also a new Xbox Game Pass feed and a way to move between Xbox and iOS games in the same interface. The Capture Button on Backbone One works with Xbox Cloud Gaming and lets you share it as a link. It’s one of the best gaming apps I’ve seen on iOS in years, and it has big potential to create a cross-universe place to play for the biggest gaming audience in the world. It’s been updating that dashboard to get better about showing you games, exposing you to new games and letting you use its clipping features to share killer plays with your friends. In my last piece, I noted how Backbone cleverly used the accessory APIs built into iOS to offer super slick functionality for its cross-game dashboard. It’s getting bundled with Xbox Game Pass Ultimate as it launches on iOS today alongside the xCloud game streaming service.Īs a part of the deal, Backbone is being bundled with Xbox Game Pass in a new retail packaging that gets the Designed for Xbox stamp, making a Backbone + iPhone combo the closest thing we’ve ever seen to a portable Xbox. Backbone One, the killer iPhone game pad I profiled here late last year, has just scored the mother of all tie-ups for a gaming accessory. ![]() Haksar grappled with Soviet attempts to gain leverage with Pakistan with the argument that Russia was weaning away Pakistan from China for its own reasons because “close understanding between Pakistan and China may bring nuclear tipped missiles aimed not only at India but the Southern flank of Soviet Union.” Therefore, the dangers of Pakistan and China colluding were not only for India but also for the Soviet Union, and that too in nuclear terms. Haksar acutely felt a “growing convergence of interest in Washington, Peking and Moscow of keeping India under pressure and using Pakistan for the purpose.” He also wrote of both Moscow and Washington having similar a view on balancing India and Pakistan: “making the development of nuclear arms by her (India) that much more difficult by providing measured quantities of arms to Pakistan.” It also gives a window to understanding the Russia-Pakistan rapprochement that was taking place, which had implications for China’s nuclear strategy towards both India and Soviet Union. The Indian long telegram assesses the great power approach to Indian nuclear ambition. A study of it is central to any constructions of Indian strategic thought. The long telegram also carried an unsparing assessment of Pakistan as “an unstable state contrived artificially” whose internal logic compelled the “inevitable and chronic hostility of Pakistan to India.” Haksar was India’s Kennan and much of what he assessed has become part of India’s enduring strategic culture. This was India’s equivalent of George Kennan’s “long telegram” to the State Department. Haksar wrote this for the benefit of the Indian prime minister almost fifty years ago. Haksar seemed to appreciate nuclear balancing in Europe and wrote of India’s “own security require that she becomes a nuclear power to establish a genuine balance of power with China.” The nuclear specter of China remained the overwhelming consideration. Haksar also reveals his thought that India’s nuclear ambition should be clearly communicated with the United States at a relevant time. Haksar distinguished between the role of nuclear India as opposed to other nuclear powers. which will be difficult to import from abroad increasingly ![]() This nuclear arms program should be based on adequate stockpiling of those sensitive instruments and machinery…. The development simultaneously of submarines driven by nuclear power fitted out to carry nuclear missiles the making of nuclear arms in the shape of medium range (2,000-3,000 miles) capable, from sites within India’s frontiers, of striking with success not only a few chosen targets in Tibet but of ranging as far afield as the industrial heart of China in Manchuria and in the great river valleys south of it which include some of her principal industries and urban centers of population It revises arguments such as those of George Perkovich, that, in the second half of the sixties, “the (Indian) scientists acted without benefit of a national security strategy or requirement.” The documents reveal disquiet among India’s strategists about China’s repeated nuclear tests from 1964 onwards. However, newly declassified documents from the prime minister’s office, which include letters between the prime minister’s office and the Department of Atomic Energy, as well as correspondence between the prime minister and scientists help establish the specific considerations that went into the making of India’s nuclear doctrine. There is still no consensus on what the historical reasons were for India to cross the no-bomb line or what internal discussions were taking place between the scientists and the prime minister’s office. We have had little historical perspective on how Indian doctrine has absorbed Chinese and Pakistan nuclear threats ever since India carried out its first underground nuclear test - “Smiling Buddha” - in May 1974. However, the only available document on Indian nuclear policy has been the “Draft Nuclear Doctrine,” which has fostered perpetual speculation on the vector and valences of Indian strategic doctrine. Indian Defense Minister Manohar Parrikar recently made a controversial “personal” comment that perhaps India must revisit its no first-use nuclear policy. ![]() ![]() Charging cables can stay plugged in to keep your devices fully powered, Simply apply a Metal Plate directly to your device or to the exterior of the case and it will always be ready to mount with a powerful bump-free hold, Mount any device including large iPads & Tablets & smartphones to your headrest and create an Interactive Multimedia Hub to keep your passengers happy. 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